{"id":8710,"date":"2025-01-15T09:41:33","date_gmt":"2025-01-15T06:41:33","guid":{"rendered":"https:\/\/www.egemtv.com\/?p=8710"},"modified":"2025-01-15T09:41:37","modified_gmt":"2025-01-15T06:41:37","slug":"meme-kanserinde-koruyucu-ameliyatlarin-faydasi-kanitlandi","status":"publish","type":"post","link":"https:\/\/www.egemtv.com\/?p=8710","title":{"rendered":"Meme kanserinde \u2018koruyucu ameliyatlar\u0131n\u2019 faydas\u0131 kan\u0131tland\u0131"},"content":{"rendered":"

\u00dcnl\u00fc oyuncu Angelina Jolie, annesini yumurtal\u0131k kanserinden kaybetmesinin ard\u0131ndan kendisinin de meme ve yumurtal\u0131k kanseri riski ta\u015f\u0131d\u0131\u011f\u0131n\u0131 \u00f6\u011frenip her iki memesini de ald\u0131rmas\u0131yla t\u00fcm d\u00fcnyan\u0131n dikkatini \u00e7ekmi\u015fti. Konuyla ilgili \u2018risk azalt\u0131c\u0131 ameliyatlar\u0131n faydas\u0131n\u0131n kan\u0131tland\u0131\u011f\u0131n\u0131\u2019 s\u00f6yleyen Do\u00e7. Dr. Ahmet \u00d6zveren, \u201cBu kan\u0131tlar San Antonio Meme Kanseri Sempozyumu\u2019nda (SABCS) sunuldu. Art\u0131k hastalar\u0131m\u0131z\u0131n koruyucu ameliyatlar konusundaki sorular\u0131na bu veriler \u00fczerinden cevap verebilece\u011fiz\u201d dedi.
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Ac\u0131badem Kent Onkoloji Merkezi T\u0131bbi Onkoloji Uzman\u0131 Do\u00e7. Dr. Ahmet \u00d6zveren, ge\u00e7en 10-13 Aral\u0131k tarihlerinde ABD\u2019nin San Antonio \u015fehrinde d\u00fczenlenen, 11 binden fazla ki\u015finin y\u00fcz y\u00fcze ve \u00e7evrimi\u00e7i kat\u0131ld\u0131\u011f\u0131 San Antonio Meme Kanseri Sempozyumu\u2019nda sunulan \u00e7al\u0131\u015fmalar\u0131n sonu\u00e7lar\u0131n\u0131 de\u011ferlendirdi. Do\u00e7. Dr. \u00d6zveren, meme ve yumurtal\u0131k kanseri yatk\u0131nl\u0131k genleri olarak bilinen BRCA mutasyonu olan ve erken ba\u015flang\u0131\u00e7l\u0131 meme kanseri \u00f6yk\u00fcs\u00fc olan hastalar\u0131n risk azalt\u0131c\u0131 cerrahilerden fayda g\u00f6r\u00fcp g\u00f6rmedi\u011fi konusunda yap\u0131lan \u00e7al\u0131\u015fmalardan \u2018yol g\u00f6sterici\u2019 sonu\u00e7lar al\u0131nd\u0131\u011f\u0131n\u0131 s\u00f6yledi. Do\u00e7. Dr. \u00d6zveren \u015funlar\u0131 kaydetti:
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\u201cBu \u00e7al\u0131\u015fmalarda BRCA mutasyonu ta\u015f\u0131y\u0131c\u0131s\u0131 olup 40 ya\u015f\u0131ndan k\u00fc\u00e7\u00fck ilk kez meme kanseri tan\u0131s\u0131 alm\u0131\u015f olanlarda risk azalt\u0131c\u0131 mastektomi veya salpingo-ooferektomi (yumurtal\u0131klardan ve fallop t\u00fcplerinden birinin (tek tarafl\u0131) veya her ikisinin (\u00e7ift tarafl\u0131) \u00e7\u0131kar\u0131lmas\u0131 i\u015flemi) yapt\u0131rman\u0131n genel sa\u011f kal\u0131m ve hastal\u0131ks\u0131z sa\u011fkal\u0131m a\u00e7\u0131s\u0131ndan anlaml\u0131 d\u00fczeyde iyile\u015fme ile ili\u015fkili oldu\u011fu g\u00f6r\u00fclm\u00fc\u015f. Bu k\u00fcresel \u00e7al\u0131\u015fma, erken ba\u015flang\u0131\u00e7l\u0131 meme kanseri \u00f6yk\u00fcs\u00fc olan gen\u00e7 BRCA mutasyon ta\u015f\u0131y\u0131c\u0131lar\u0131 aras\u0131nda risk azalt\u0131c\u0131 ameliyatlar\u0131n sa\u011fkal\u0131m sonu\u00e7lar\u0131n\u0131 iyile\u015ftirdi\u011fine dair kan\u0131t sa\u011fl\u0131yor.\u201d<\/p>\n

\u201cGen\u00e7 pop\u00fclasyonlarda cerrahi m\u00fcdahalelerin etkisi daha az belirgin\u201d
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BRCA mutasyon ta\u015f\u0131y\u0131c\u0131s\u0131 olup kanser \u00f6yk\u00fcs\u00fc olmayan ki\u015filere, risk azalt\u0131c\u0131 cerrahi m\u00fcdahaleler de dahil olmak \u00fczere \u00e7e\u015fitli risk azalt\u0131c\u0131 stratejilerin \u00f6nerilmekte oldu\u011funu aktaran Do\u00e7. Dr. \u00d6zveren, \u201cAncak erken ba\u015flang\u0131\u00e7l\u0131 meme kanseri \u00f6yk\u00fcs\u00fc olan daha gen\u00e7 pop\u00fclasyonlarda bu cerrahi m\u00fcdahalelerin etkisi daha az belirgindir. \u00c7al\u0131\u015fma muhtemel patojenik\/patojenik germ hatt\u0131 BRCA1 ve\/veya BRCA2 mutasyonlar\u0131 olan ve 40 ya\u015f\u0131ndan k\u00fc\u00e7\u00fck evre I-III meme kanseri tan\u0131s\u0131 konmu\u015f 5 bin 290 hastay\u0131 kapsayan uluslararas\u0131, \u00e7ok merkezli, retrospektif bir kohort (kay\u0131tlardan geriye d\u00f6n\u00fck izlemler yap\u0131lan ara\u015ft\u0131rmalar) \u00e7al\u0131\u015fmas\u0131d\u0131r\u201d diye konu\u015ftu.<\/p>\n

Mastektomi analizi sonu\u00e7lar\u0131
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Do\u00e7. Dr. \u00d6zveren, risk azalt\u0131c\u0131 mastektomi analizinin, tan\u0131dan itibaren 1 y\u0131ldan k\u0131sa bir s\u00fcre i\u00e7inde ameliyata giren 2 bin 910 hasta ile ameliyat olmamay\u0131 tercih eden 2 bin 380 hastay\u0131 kapsad\u0131\u011f\u0131n\u0131 s\u00f6yledi. 5,1 y\u0131ll\u0131k medyan (bir veri k\u00fcmesindeki orta de\u011fer) takip s\u00fcresince, risk azalt\u0131c\u0131 mastektomi ge\u00e7iren hastalar\u0131n \u00f6lme riskinin y\u00fczde 35 daha d\u00fc\u015f\u00fck bulundu\u011funu kaydeden Do\u00e7. Dr. \u00d6zveren, \u201cAyr\u0131ca hastal\u0131ks\u0131z sa\u011f kal\u0131mda y\u00fczde 42\u2019lik bir risk azalmas\u0131 oldu\u011fu g\u00f6r\u00fcld\u00fc\u201d dedi.<\/p>\n

\u201cBu analiz de 5 bin 290 hasta ile yap\u0131ld\u0131\u201d
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Do\u00e7. Dr. \u00d6zveren, risk azalt\u0131c\u0131 salpingo-ooferektomi analizinin de tan\u0131dan itibaren 3 y\u0131l sonra bu ameliyat\u0131 ge\u00e7iren 2 bin 782 ve ge\u00e7irmeyen 2 bin 508 hasta olmak \u00fczere toplam 5 bin 290 hastay\u0131 kapsad\u0131\u011f\u0131n\u0131 belirterek s\u00f6zlerini \u015f\u00f6yle s\u00fcrd\u00fcrd\u00fc:
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\u201cOrtalama 4,9 y\u0131ll\u0131k takip s\u00fcresince, risk azalt\u0131c\u0131 salpingo-ooferektomi y\u00fczde 42 daha d\u00fc\u015f\u00fck \u00f6l\u00fcm riski ve hastal\u0131ks\u0131z sa\u011f kal\u0131mda y\u00fczde 32 risk azalmas\u0131 ile ili\u015fkilendirildi. Bu t\u00fcr veri k\u00fcmelerine sahip olmak, hastalara \u2018ameliyat olarak sahip olduklar\u0131 riski azaltma miktar\u0131na dair potansiyel olarak en iyi tahminimizi\u2019 vermemize yard\u0131mc\u0131 oluyor. Ayr\u0131ca bu \u00e7al\u0131\u015fma verilerine dayanarak bu mutasyonlar\u0131 tespit etti\u011fimiz meme-over kanserli hastalar\u0131m\u0131zda \u2018yine de koruyucu ameliyat olmasam olur mu?\u2019 sorusuna daha net cevap verebilmekteyiz.\u201d<\/p>\n

\u201c\u0130lk duydu\u011fumda \u015fok oldum\u201d
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2020 y\u0131l\u0131nda elle muayene s\u0131ras\u0131nda memesinde kitle hisseden ve ard\u0131ndan muayene olan Neslihan Ergin (42), \u201cMeme kanseri oldu\u011fum tan\u0131s\u0131yla ameliyat oldum. Kitle hemen al\u0131nd\u0131. \u0130lk duydu\u011fumda \u015fok oldum \u00e7\u00fcnk\u00fc ailemde ve akrabalar\u0131mda hi\u00e7 kimsede meme kanseri yok. \u0130lk defa bende \u00e7\u0131kt\u0131\u011f\u0131 i\u00e7in bunun olabilece\u011fine inanmad\u0131m. Muayene ve erken tan\u0131yla birlikte operasyon ge\u00e7irdim. Kemoterapilerim oldu. \u015eu an gayet iyiyim\u201d ifadelerine yer verdi.
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\"\"\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00dcnl\u00fc oyuncu Angelina Jolie, annesini yumurtal\u0131k kanserinden kaybetmesinin ard\u0131ndan kendisinin de meme ve yumurtal\u0131k kanseri riski ta\u015f\u0131d\u0131\u011f\u0131n\u0131 \u00f6\u011frenip her iki memesini de ald\u0131rmas\u0131yla t\u00fcm d\u00fcnyan\u0131n dikkatini \u00e7ekmi\u015fti. Konuyla ilgili \u2018risk azalt\u0131c\u0131 ameliyatlar\u0131n faydas\u0131n\u0131n kan\u0131tland\u0131\u011f\u0131n\u0131\u2019 s\u00f6yleyen Do\u00e7. Dr. Ahmet \u00d6zveren, \u201cBu kan\u0131tlar San Antonio Meme Kanseri Sempozyumu\u2019nda (SABCS) sunuldu. Art\u0131k hastalar\u0131m\u0131z\u0131n koruyucu ameliyatlar konusundaki sorular\u0131na bu…<\/p>\n","protected":false},"author":1,"featured_media":8711,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","footnotes":""},"categories":[2],"tags":[],"class_list":["post-8710","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"_links":{"self":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts\/8710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8710"}],"version-history":[{"count":1,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts\/8710\/revisions"}],"predecessor-version":[{"id":8714,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts\/8710\/revisions\/8714"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/media\/8711"}],"wp:attachment":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}