Prof. Dr. Burak Turna, meme ve prostat kanserlerinin farkl\u0131 organlarda g\u00f6r\u00fclmesine ra\u011fmen \u00f6nemli genetik ortakl\u0131klar ta\u015f\u0131d\u0131\u011f\u0131n\u0131 s\u00f6yledi. BRCA mutasyonlar\u0131n\u0131n ortak risk fakt\u00f6r\u00fc oldu\u011funu belirten Prof. Dr. Turna, “Bu nedenle aile \u00f6yk\u00fcs\u00fc genetik de\u011ferlendirmelerin en kritik a\u015famalar\u0131ndan biri haline geldi. Kanser t\u00fcrleri aras\u0131ndaki genetik ba\u011flant\u0131lar\u0131n anla\u015f\u0131lmas\u0131 ki\u015fiye \u00f6zel sa\u011fl\u0131k stratejilerinin geli\u015ftirilmesi a\u00e7\u0131s\u0131ndan \u00e7ok \u00f6nemli.” dedi.
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Ac\u0131badem Kent Hastanesi \u00dcroloji Uzman\u0131 Prof. Dr. Burak Turna prostat kanserinde erken tan\u0131 ve g\u00fcncel tedavi yakla\u015f\u0131mlar\u0131 konusunda bilgi verirken, meme ve prostat kanserlerinin genetik ili\u015fkilerine dikkat \u00e7ekti.<\/p>\n
BRCA mutasyonlar\u0131 ortak risk fakt\u00f6r\u00fc
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Prof. Dr. Turna, genetik ili\u015fkiler konusunda \u015funlar\u0131 s\u00f6yledi: “\u00d6zellikle BRCA1 ve BRCA2 genlerindeki mutasyonlar kad\u0131nlarda meme ve over, erkeklerde ise daha gen\u00e7 ya\u015fta ortaya \u00e7\u0131kan agresif prostat kanseri riskini belirgin \u015fekilde art\u0131r\u0131yor. Genetik de\u011ferlendirmelerde aile \u00f6yk\u00fcs\u00fc bu nedenle \u00e7ok \u00f6nem kazan\u0131yor. Erken ya\u015fta veya agresif tipte meme kanseri tan\u0131s\u0131 alan bir annede BRCA mutasyonu bulunmas\u0131 durumunda, o\u011flunun prostat kanseri a\u00e7\u0131s\u0131ndan genetik de\u011ferlendirmeye al\u0131nmas\u0131 gerekir. Ayn\u0131 \u015fekilde metastatik ya da y\u00fcksek dereceli prostat kanseri tan\u0131s\u0131 olan bir baban\u0131n k\u0131z\u0131nda meme kanseri riskini art\u0131ran genetik de\u011fi\u015fiklikler g\u00f6r\u00fclebilir.”<\/p>\n
Meme ve prostat kanserinde y\u00fcksek s\u0131kl\u0131k
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\u00d6te yandan Prof. Dr. Turna, T\u00fcrkiye ve d\u00fcnyada kad\u0131nlarda en s\u0131k g\u00f6r\u00fclen kanser t\u00fcr\u00fcn\u00fcn meme kanseri oldu\u011funu hat\u0131rlatt\u0131, her 8 kad\u0131ndan birinin ya\u015fam\u0131 boyunca bu hastal\u0131\u011fa yakalanabilece\u011fini s\u00f6yledi. Prostat kanserinin de erkeklerde en yayg\u0131n g\u00f6r\u00fclen kanser t\u00fcrlerinden biri oldu\u011funu belirten Prof. Dr. Turna, “Bu kanserin erkeklerde ya\u015fam boyu g\u00f6r\u00fclme riski y\u00fczde 12-15 seviyelerinde. Bu y\u00fcksek oranlar, iki hastal\u0131\u011f\u0131n ortak genetik temelini anlamay\u0131 daha da \u00f6nemli hale getiriyor.” dedi.
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Prof. Dr. Turna, genetik analizlerin sadece risk belirlemek i\u00e7in de\u011fil, erken tan\u0131 stratejilerinin olu\u015fturulmas\u0131nda kritik \u00f6nemde oldu\u011funu s\u00f6yledi. Genetik analizlerin ayr\u0131ca gereksiz tedavilerin \u00f6nlenmesinde, aile bireylerinin risk d\u00fczeylerinin belirlenmesinde \u00f6nemli oldu\u011funu vurgulayan Prof. Dr. Turna, “PARP inhibit\u00f6rleri (baz\u0131 kanser h\u00fccrelerindeki bozulmu\u015f DNA onar\u0131m mekanizmalar\u0131ndan yararlanarak se\u00e7ici kanser h\u00fccresi \u00f6l\u00fcm\u00fcne yol a\u00e7an bir hedefli kanser ilac\u0131 s\u0131n\u0131f\u0131d\u0131r) gibi hedefe y\u00f6nelik tedavilerin planlanmas\u0131 a\u00e7\u0131s\u0131ndan da genetik analizlerin \u00f6nemi b\u00fcy\u00fck.” diye konu\u015ftu.
<\/p>\n","protected":false},"excerpt":{"rendered":"
Prof. Dr. Burak Turna, meme ve prostat kanserlerinin farkl\u0131 organlarda g\u00f6r\u00fclmesine ra\u011fmen \u00f6nemli genetik ortakl\u0131klar ta\u015f\u0131d\u0131\u011f\u0131n\u0131 s\u00f6yledi. BRCA mutasyonlar\u0131n\u0131n ortak risk fakt\u00f6r\u00fc oldu\u011funu belirten Prof. Dr. Turna, “Bu nedenle aile \u00f6yk\u00fcs\u00fc genetik de\u011ferlendirmelerin en kritik a\u015famalar\u0131ndan biri haline geldi. Kanser t\u00fcrleri aras\u0131ndaki genetik ba\u011flant\u0131lar\u0131n anla\u015f\u0131lmas\u0131 ki\u015fiye \u00f6zel sa\u011fl\u0131k stratejilerinin geli\u015ftirilmesi a\u00e7\u0131s\u0131ndan \u00e7ok \u00f6nemli.” dedi. Ac\u0131badem…<\/p>\n","protected":false},"author":1,"featured_media":75089,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","footnotes":""},"categories":[2],"tags":[],"class_list":["post-75088","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"_links":{"self":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts\/75088","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=75088"}],"version-history":[{"count":1,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts\/75088\/revisions"}],"predecessor-version":[{"id":75090,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts\/75088\/revisions\/75090"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/media\/75089"}],"wp:attachment":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=75088"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=75088"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=75088"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}