Ayd\u0131n Adnan Menderes \u00dcniversitesi (AD\u00dc) Teknokent\u2019te faaliyetlerini s\u00fcrd\u00fcren Karya Farma HBX Ar-Ge tabiattaki biyolojik savunma sisteminden esinlenerek yapt\u0131klar\u0131 \u00e7al\u0131\u015fmada kanserle m\u00fccadelede yeni bir metot \u00fczerinde durduklar\u0131n\u0131 a\u00e7\u0131klad\u0131.
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Yakla\u015f\u0131k \u00e7eyrek as\u0131rdan bu yana s\u00fcrd\u00fcrd\u00fckleri \u00e7al\u0131\u015fmalarda s\u00fcrekli do\u011fay\u0131 izleyerek ilerlediklerini kaydeden Karya Farma HBX Ar-Ge Kurucusu Hakan Ba\u015fl\u0131k, “Do\u011fay\u0131 taklit etmiyoruz, do\u011fay\u0131 anlamaya \u00e7al\u0131\u015f\u0131yoruz. Fillerden k\u00f6pek bal\u0131klar\u0131na, y\u0131lan bal\u0131klar\u0131ndan asalak bitkilere kadar her biyolojik yap\u0131 bize kanserle sava\u015fta farkl\u0131 bir savunma modeli sunuyor. HBX sistemleri; h\u00fccreyi de\u011fil, organizmay\u0131 koruma sistemini esas al\u0131yor. Bu anlay\u0131\u015ftan yola \u00e7\u0131karak kanser tedavisinde biyolojik savunma y\u00f6ntemi ile yeni bir s\u00fcre\u00e7 ba\u015flatmak i\u00e7in \u00e7al\u0131\u015f\u0131yoruz” dedi.
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Bug\u00fcn 18 ayr\u0131 patente sahip olan Karya Farma HBX Ar-Ge\u2019nin geli\u015ftirdi\u011fi HBX patent ailesi ve HBX-2371 form\u00fclasyonunun, tabiattaki biyolojik savunma sistemlerinden esinlenerek ortaya \u00e7\u0131kar\u0131ld\u0131\u011f\u0131n\u0131 kaydeden Ba\u015fl\u0131k, kanserle m\u00fccadelede yeni bir b\u00fct\u00fcnc\u00fcl biyoteknolojik yakla\u015f\u0131m \u00fczerinde \u00e7al\u0131\u015ft\u0131klar\u0131n\u0131 s\u00f6yledi.
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Ba\u015fl\u0131k konuyla ilgili a\u00e7\u0131klamas\u0131nda; “Kanser, modern t\u0131bb\u0131n en karma\u015f\u0131k ve \u00f6l\u00fcmc\u00fcl sorunlar\u0131ndan biri olmaya devam ediyor. Genetik mutasyonlardan ba\u011f\u0131\u015f\u0131kl\u0131k sistemine, oksidatif stresten h\u00fccresel mikro\u00e7evreye kadar bir\u00e7ok fakt\u00f6r\u00fcn e\u015f zamanl\u0131 etkisiyle ortaya \u00e7\u0131kan bu hastal\u0131k, yaln\u0131zca t\u00fcm\u00f6r bask\u0131lamaya odakl\u0131 klasik tedavilerin s\u0131n\u0131rlar\u0131n\u0131 zorlamaya ba\u015flad\u0131. \u0130\u015fte tam da bu noktada Karya Farma HBX Ar-Ge ekibi olarak, \u00e7oklu sistem hedefli ve do\u011fadan esinlenen biyoteknolojik bir \u00e7\u00f6z\u00fcm modeli \u00fczerinde \u00e7al\u0131\u015fmaya ba\u015flad\u0131k. Bu \u00e7al\u0131\u015fma kanser biyolojisinin farkl\u0131 zay\u0131f noktalar\u0131n\u0131 hedefleyen 5 \u00f6zg\u00fcn bile\u015fim i\u00e7eriyor. Bu sistemin temel amac\u0131, yaln\u0131zca t\u00fcm\u00f6r odakl\u0131 de\u011fil, organizman\u0131n t\u00fcm biyolojik savunma hatlar\u0131n\u0131 aktive ederek \u00e7oklu hedefli bir m\u00fccadele stratejisi kurmak” diye konu\u015ftu.
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\u00c7al\u0131\u015fmalar\u0131 esnas\u0131nda tabiattaki milyonlarca y\u0131ll\u0131k evrimsel savunma mekanizmalar\u0131ndan esinlenerek yol ald\u0131klar\u0131n\u0131 belirten Ba\u015fl\u0131k, “\u0130nsanlarda 2 adet bulunan TP53 t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 geni, filler \u00fczerinde 20\u2019den fazla kopyaya sahip. Bu sayede filler, DNA hasar\u0131na kar\u015f\u0131 kendini s\u00fcrekli koruyarak t\u00fcm\u00f6r olu\u015fum riskini minimize ediyor. HBX-2371, fillerin bu genetik avantaj\u0131n\u0131 biyomimetik modelleme ile de\u011ferlendiriyor. K\u00f6pek bal\u0131klar\u0131, y\u00fcksek ba\u011f\u0131\u015f\u0131kl\u0131k g\u00fcc\u00fc ve damar olu\u015fumunu bask\u0131layan do\u011fal proteinleri sayesinde kansere kar\u015f\u0131 \u00fcst\u00fcn koruma sa\u011flar. HBX-2371 geli\u015ftirilirken k\u00f6pek bal\u0131\u011f\u0131n\u0131n angiogenez bask\u0131lay\u0131c\u0131 proteinlerinden esinleniyor. D\u00fc\u015f\u00fck oksijenli sularda bile ya\u015fayabilen y\u0131lan bal\u0131klar\u0131, mitokondri d\u00fczeyindeki dayan\u0131kl\u0131l\u0131\u011f\u0131yla oksidatif stresi minimize ediyor. HBX-2371\u2019in h\u00fccresel stres fakt\u00f6rlerine kar\u015f\u0131 direncinde bu mekanizmalar \u00f6rnek al\u0131n\u0131yor. \u00d6te yandan asalak ya\u015fam d\u00f6ng\u00fcs\u00fcne sahip \u00f6kse otu, ba\u011f\u0131\u015f\u0131kl\u0131k sistemini T h\u00fccreleri \u00fczerinden aktive ediyor ve t\u00fcm\u00f6r h\u00fccrelerinde apoptoz mekanizmas\u0131n\u0131 \u00e7al\u0131\u015ft\u0131r\u0131yor. Dikenli bitkiler ise fenolik bile\u015fik i\u00e7erikleriyle DNA hasar\u0131n\u0131 \u00f6nleyici do\u011fal antioksidanlar sa\u011fl\u0131yor” diyerek \u00e7al\u0131\u015fmalar\u0131nda tabiattan esinlendiklerini ve kanserle b\u00fct\u00fcnc\u00fcl m\u00fccadele edeceklerini s\u00f6yledi.
<\/p>\n","protected":false},"excerpt":{"rendered":"
Ayd\u0131n Adnan Menderes \u00dcniversitesi (AD\u00dc) Teknokent\u2019te faaliyetlerini s\u00fcrd\u00fcren Karya Farma HBX Ar-Ge tabiattaki biyolojik savunma sisteminden esinlenerek yapt\u0131klar\u0131 \u00e7al\u0131\u015fmada kanserle m\u00fccadelede yeni bir metot \u00fczerinde durduklar\u0131n\u0131 a\u00e7\u0131klad\u0131. Yakla\u015f\u0131k \u00e7eyrek as\u0131rdan bu yana s\u00fcrd\u00fcrd\u00fckleri \u00e7al\u0131\u015fmalarda s\u00fcrekli do\u011fay\u0131 izleyerek ilerlediklerini kaydeden Karya Farma HBX Ar-Ge Kurucusu Hakan Ba\u015fl\u0131k, “Do\u011fay\u0131 taklit etmiyoruz, do\u011fay\u0131 anlamaya \u00e7al\u0131\u015f\u0131yoruz. Fillerden k\u00f6pek bal\u0131klar\u0131na,…<\/p>\n","protected":false},"author":1,"featured_media":34791,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","footnotes":""},"categories":[124],"tags":[],"class_list":["post-34790","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim"],"_links":{"self":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts\/34790","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34790"}],"version-history":[{"count":1,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts\/34790\/revisions"}],"predecessor-version":[{"id":34792,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/posts\/34790\/revisions\/34792"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=\/wp\/v2\/media\/34791"}],"wp:attachment":[{"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34790"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34790"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.egemtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}